(R)-1-TERT-BUTYL 2-METHYL PIPERAZINE-1,2-DICARBOXYLATE
(R)-N-Boc-piperazine-2-carboxylic acid methyl ester
CAS: 252990-05-9
Molecular Formula: C11H20N2O4
(R)-1-TERT-BUTYL 2-METHYL PIPERAZINE-1,2-DICARBOXYLATE - Names and Identifiers
(R)-1-TERT-BUTYL 2-METHYL PIPERAZINE-1,2-DICARBOXYLATE - Physico-chemical Properties
| Molecular Formula | C11H20N2O4 |
| Molar Mass | 244.29 |
| Density | 1.118±0.06 g/cm3(Predicted) |
| Boling Point | 321.3±37.0 °C(Predicted) |
| Flash Point | 148.1°C |
| Vapor Presure | 0.000301mmHg at 25°C |
| pKa | 7.25±0.40(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.471 |
(R)-1-TERT-BUTYL 2-METHYL PIPERAZINE-1,2-DICARBOXYLATE - Introduction
(R)-N-Boc-piperazine-2-carboxylic acid methyl ester ((R)-N-Boc-piperazine-2-carboxylic acid methyl ester) is a compound with the following properties and uses:
Nature:
-Appearance: Colorless liquid or solid
-Molecular formula: C11H20N2O3
-Molecular weight: 232.29g/mol
-Melting point: 57-60 ° C
-Boiling point: 271 ° C
-Stability: Stable at room temperature, soluble in some organic solvents.
Use:
- (R)-N-Boc-piperazine-2-carboxylic acid methyl ester is widely used in organic synthesis. It is a chiral reagent in organic synthesis and can be used in the synthesis of chiral drugs. It can be used as a chiral intermediate or catalyst to participate in the synthesis of chiral compounds, such as asymmetric addition and reduction reactions.
Method:
(R)-The preparation of N-Boc-piperazine-2-carboxylic acid methyl ester is generally carried out by organic synthesis methods. The specific preparation method includes the following steps:
1. Reacting 2-piperazinecarboxylic acid with 1-hydroxy-2-methoxyethanone to obtain methyl piperazinecarboxylate;
2. React the obtained methyl piperazinecarboxylate with Boc acylating reagent to obtain (R)-N-Boc-piperazine-2-carboxylic acid methyl ester.
Safety Information:
(R)-N-Boc-piperazine-2-carboxylic acid methyl ester is generally relatively safe under correct operation. However, it is still a chemical substance that may cause some harm to the human body. Observe proper laboratory practices and personal protective measures when using or handling. Avoid direct contact with skin and eyes, wear appropriate protective gloves and glasses if necessary. During storage and handling, it should be kept in a dry, well-ventilated place, and away from fire or heat sources.
In general, the use and handling of (R)-N-Boc-piperazine-2-carboxylic methyl ester should follow the relevant safety operation guidelines and be carried out in a safe environment.
Nature:
-Appearance: Colorless liquid or solid
-Molecular formula: C11H20N2O3
-Molecular weight: 232.29g/mol
-Melting point: 57-60 ° C
-Boiling point: 271 ° C
-Stability: Stable at room temperature, soluble in some organic solvents.
Use:
- (R)-N-Boc-piperazine-2-carboxylic acid methyl ester is widely used in organic synthesis. It is a chiral reagent in organic synthesis and can be used in the synthesis of chiral drugs. It can be used as a chiral intermediate or catalyst to participate in the synthesis of chiral compounds, such as asymmetric addition and reduction reactions.
Method:
(R)-The preparation of N-Boc-piperazine-2-carboxylic acid methyl ester is generally carried out by organic synthesis methods. The specific preparation method includes the following steps:
1. Reacting 2-piperazinecarboxylic acid with 1-hydroxy-2-methoxyethanone to obtain methyl piperazinecarboxylate;
2. React the obtained methyl piperazinecarboxylate with Boc acylating reagent to obtain (R)-N-Boc-piperazine-2-carboxylic acid methyl ester.
Safety Information:
(R)-N-Boc-piperazine-2-carboxylic acid methyl ester is generally relatively safe under correct operation. However, it is still a chemical substance that may cause some harm to the human body. Observe proper laboratory practices and personal protective measures when using or handling. Avoid direct contact with skin and eyes, wear appropriate protective gloves and glasses if necessary. During storage and handling, it should be kept in a dry, well-ventilated place, and away from fire or heat sources.
In general, the use and handling of (R)-N-Boc-piperazine-2-carboxylic methyl ester should follow the relevant safety operation guidelines and be carried out in a safe environment.
Last Update：2024-04-09 20:45:29
